Problems and new developments in the treatment of acute and chronic brucellosis in man
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Reduced IFN-γ Production in Chronic Brucellosis Patients
Background: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. Objective: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. Methods: In this cross-sectional study, 22 individuals w...
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Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...
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Background: Brucellosis is one of the most common chronic diseases, with widespread distribution. In spite of cell-mediated immunity (CMI) modulated mainly via activated T-helper type 1 (Th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. Regulatory T cells (Treg cells) are involved the immune response to brucellosis; however, their role, particularly in...
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Neurobrucellosis (N.B) is a rare and severe form of systemic Brucella infection. We introduced an unusual case that “Psychologic Symptoms” was the most prominent complaints of his family. He was a 50-year-old man who has worked in butchery. His problems had begun 2 months prior to his admission with mood disorders, arthralgia, weakness, headache, and night sweats; he has recurrent crying with n...
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Brucellosis is an endemic disease in Iran that is transmitted from animal to human. The clinical manifestations of brucellosis are nonspecific and its complications involve bones and joints. Brucellosis osteomyelitis can mimic the manifestations of neoplasms; therefore, it cannot readily be diagnosed in some cases. Under such circumstances, high incidence can be a helpful factor. We reported a...
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Background and purpose:Brucellosis is a disease with zoonotic and transmissible world wide distribution which, often becomes chronic with high rate of recurrence. Since the immune responses during brucellosis have not been studied profoundly, therefore in this study cytokine production in the patients suffering from brucellosis and in healthy individuals has been evaluated. Materials and met...
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